; Nicholson, T.; Kahler, B.; Walsh, L.J. Int Endod J. The statements, opinions and data contained in the journals are solely 30. Author to whom correspondence should be addressed. 2018 Feb;51(2):177-205. doi: 10.1111/iej.12841. Therefore, the null hypothesis was accepted. Giraud, T.; Jeanneau, C.; Bergmann, M.; Laurent, P.; About, I. Tricalcium Silicate Capping Materials Modulate Pulp Healing and Inflammatory Activity In Vitro. Adhesion and marginal adaptation of a claimed bioactive, restorative material. Corral, C.; Negrete, P.; Estay, J.; Osorio, S.; Covarrubias, C.; De Oliveira Junior, O.B. Materials and Methods: A longitudinal interventional single-blind randomized clinical trial was conducted on 94 children (7–12 years) with a deep carious lesion in one or more primary second molar and permanent first molar without the history of spontaneous pain indicated for indirect pulp capping (IPC) procedure. Bjørndal, L.; Simon, S.; Tomson, P.L. Karadas, M.; Cantekin, K.; Gumus, H.; Ateş, S.M. This site needs JavaScript to work properly. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. ; Lim, K.C. HHS Torabinejad, M.; Watson, T.F. Pameijer, C.H. Li, X.; De Munck, J.; Van Landuyt, K.; Pedano, M.; Chen, Z.; Van Meerbeek, B. 2019 doi: 10.1111/aej.12392. ; Alothmani, O.S. Long-term Pulpal and Restorative Outcomes of Pulpotomy in Mature Permanent Teeth. The present findings confirm that both MTA and Biodentine are reliable materials in the matter of inducing dentin bridge formation while keeping a vital pulp in both direct and indirect pulp capping procedures [. ; Abrantes, A.M.; Casalta-Lopes, J.; Gonçalves, A.C.; Sarmento-Ribeiro, A.B. NLM Grech, L.; Mallia, B.; Camilleri, J. Tan, S.Y. ; Piva, E. Physical and Biological Properties of a High-Plasticity Tricalcium Silicate Cement. ; Kucukyilmaz, E.; Sari, T. Evaluation of temperature changes in the pulp chamber during polymerization of light-cured pulp-capping materials by using a VALO LED light curing unit at different curing distances. In the present study, no differences were observed in the outcomes between the two indirect pulp-capping materials, and both materials exhibited very similar success rates. Calcium hydroxide is the most popular agent for direct and indirect pulp capping … Despite Biodentine's superiority in relatively easier manipulation, competitive pricing and predictable clinical outcome, more long-term clinical studies on Biodentine as a pulp capping agent are needed. Ha, W.N. COVID-19 is an emerging, rapidly evolving situation. There have been several studies conducted on the success rates of direct and indirect pulp capping using a range of different materials. Pulpdent Activa BioActive White Paper. The composite materials for pulp capping are comprised of three constituents, : a resin matrix (organic part), fillers (inorganic constituent), and various coupling materials. Comparative Analysis of 2 Calcium Silicate—Based Cements (Biodentine and Mineral Trioxide Aggregate) as Direct Pulp-capping Agent in Young Permanent Molars: A Split Mouth Study. Mineral trioxide aggregate-A review of properties and testing methodologies. Nekoofar, M.H. Vital pulp therapy often means placing layers of different materials. Article Download PDF View Record in Scopus Google Scholar. The indirect pulp capping (IPC) procedure is generally used in deep cavity preparations, with or without carious dentine remaining which is in close proximity to the pulp but showing no visible pulp exposure [, One-stage selective carious-tissue removal includes the application of a biomaterial onto a dentine barrier after either firm or soft dentine is left only on the pulpal aspect of the cavity, whilst peripheral carious dentine is removed down to hard dentine on the same visit permanent restoration is being placed. The first stage involves selective carious removal to soft dentine, to an extent that facilitates proper placement of a temporary restoration, and the second stage includes removal to firm dentine. How effectively do hydraulic calcium-silicate cements re-mineralize demineralized dentin. Physiochemical properties of experimental nano-hybrid MTA. ; Shojaeian, S.H. Akhavan Zanjani, V.; Tabari, K.; Sheikh-Al-Eslamian, S.M. Biological effects and washout resistance of a newly developed fast-setting pozzolan cement. Camilleri, J.; Laurent, P.; About, I. Hydration of Biodentine, Theracal LC, and a Prototype Tricalcium Silicate–based Dentin Replacement Material after Pulp Capping in Entire Tooth Cultures. Nilsen, B.W. • 5- Biodentin • 6- Bonding systems. About, I. Dentin-pulp regeneration: The primordial role of the microenvironment and its modification by traumatic injuries and bioactive materials. About, I. Biodentine: From biochemical and bioactive properties to clinical applications. Tom As-Catal, C.J. Long-term Pulpal and Restorative Outcomes of Pulpotomy in Mature Permanent Teeth. Kamal, E.; Nabih, S.; Obeid, R.; Abdelhameed, M. The reparative capacity of different bioactive dental materials for direct pulp capping. European Society of Endodontology position statement: Management of deep caries and the exposed pulp. Comparative Study of Pulpal Responses to Pulpotomy with ProRoot MTA, RetroMTA, and TheraCal in Dogs’ Teeth. Schembri, M.; Peplow, G.; Camilleri, J. Based on the calcium (Ca, Marginal sealing is provided by micromechanical retention due to penetration of Biodentine into the dentin tubules forming tag-like structures, and represents similar bond strength to dentine compared toMTA (ProRoot MTA) [, When compared to MTA, improvements in BD properties, such as setting time, mechanical qualities and initial cohesiveness, led to widened range of applications, including endodontic repair and vital pulp therapy. One study of indirect pulp capping recorded success rates of 98.3% and 95% using bioactive tricalcium silicate [Ca3SiO5]-based dentin substitute and light-activated calcium hydroxide [CA(OH)2]-based liner respectively. Sinkar, R.; Patil, S.; Jogad, N.; Gade, V. Comparison of sealing ability of ProRoot MTA, RetroMTA, and Biodentine as furcation repair materials: An ultraviolet spectrophotometric analysis. Defined as a procedure wherein the deepest layer of the remaining affected carious dentin is covered with a layer of biocompatible material in order to prevent pulp exposure and further trauma to the pulp. Hilton, T.J. Keys to Clinical Success with Pulp Capping: A Review of the Literature. Dent. indirect pulp capping procedures using calcium hydroxide or MTA in teeth with deep carious lesions, regarding its morphological characteristics and degree of inflammation induced in the dental pulp. A correlation of in vitro and in vivo data revealed that, currently, the most validated material for pulp capping procedures is still MTA. Aust. Int.  |  Please note that many of the page functionalities won't work as expected without javascript enabled. TheraCal LC is a light-cured calcium silicate-based material designed as both a direct and indirect pulp capping material that facilitates the immediate placement of final restoration. ; Du, T.F. Guo, Y.J. A randomized controlled evaluation of posterior resin restorations of an altered resin modified glass-ionomer cement with claimed bioactivity. ; Hungaro Duarte, M.A. ; Hwang, M.-J. eCollection 2020 Dec. Front Bioeng Biotechnol. J. Endod. Indirect pulp capping materials do not enter into direct contact with the pulp; therefore, indirect contact testing was used, since it could provide more realistic in vitro conditions for testing the cytotoxicity of the adhesives. J Endod, 41 (2015), pp. Biodentine and Mineral Trioxide Aggregate: An Analysis of Solubility, pH Changes and Leaching Elements. ; Sübay, R.K.; Ostro, E.; Suzuki, S.; Suzuki, S.H. J Am Dent Assoc, … In Vitro 2010. ; Cauwels, R.G.E.C. ; Goodis, H.E. On account of its advantages, BD has recently become a preferable agent for both direct and indirect pulp capping procedures. Oral Radiol. NA—not available; SE—self-etch; DBA—dentine bonding agent. Analyses of heavy metals in mineral trioxide aggregate and Portland cement. Vital pulp therapy of mature permanent teeth with irreversible pulpitis from the perspective of pulp biology. Bioactive and Biomimetic Restorative Materials: A Comprehensive Review: Part I. Cao, C.Y. Gandolfi, M.G. 2018;11:2173 doi: 10.3390/ma11112173. The clinical applications of mineral trioxide aggregate. ; Siboni, F.; Botero, T.; Bossù, M.; Riccitiello, F.; Prati, C. Calcium silicate and calcium hydroxide materials for pulp capping: Biointeractivity, porosity, solubility and bioactivity of current formulations. Poor chemical or micromechanical adhesion, Poor chemical or micromechanical adhesion due to lack of self-adhesive properties, Less favourable odontoblastic layer formation. Three materials are most commonly used in indirect pulp treatment: the calcium hydroxide (CH), zinc oxide-eugenol paste (ZOE) and glass ionomer cements. ; Abou Neel, E.A. Materials and methods. ; Yadlapati, M.; Dorn, S.O. ; writing—original draft preparation, M.L.-S. and M.K. ; Foxton, R.; Manoharan, A.; Watson, T.F. Komabayashi, T.; Zhu, Q.; Eberhart, R.; Imai, Y. ; Bernardineli, N.; Garcia, R.B. Endod. ; Verbeeck, R.M.H. ; Neel, E.A.A. You seem to have javascript disabled. ; Yu, M.K. ; Hwang, Y.C. ; writing—review and editing, M.L.-S.; supervision M.L.-S. All authors have read and agreed to the published version of the manuscript. Several materials have been used for this procedure. Panda S, Mishra L, Arbildo-Vega HI, Lapinska B, Lukomska-Szymanska M, Khijmatgar S, Parolia A, Bucchi C, Fabbro MD. ; Aminishakib, P.; Abedi, F.; Naghi Moosavi, F.; Esnaashari, E.; Azizi, A.; Esmailian, S.; Ellini, M.R. Poggio, C.; Lombardini, M.; Colombo, M.; Beltrami, R.; Rindi, S. Solubility and pH of direct pulp capping materials: A comparative study. Bortoluzzi, E.A. ; Sharma, A. We used 60 third molars The properties and clinical performances of four calcium-silicate cements (ProRoot MTA, MTA Angelus, RetroMTA, Biodentine), a light-cured calcium silicate-based material (TheraCal LC) and an enhanced resin-modified glass-ionomer (ACTIVA BioACTIVE) are widely discussed.  |  Direct pulp-capping is a method for treating exposed vital pulp with dental material to facilitate the formation of reparative dentin and to maintain vital pulp. Two types of pulp-capping materials, calcium hydroxide and mineral trioxide aggregate, have been Aim Indirect pulp capping (IPC) is a treatment that preserves pulp vitality. ; Schäfer, E.; Dammaschke, T. Shear bond strength of Biodentine, ProRoot MTA, glass ionomer cement and composite resin on human dentine ex vivo. ; Neo, C.L.J. Indirect pulp capping in the primary dentition: a 4 year follow-up study. ; Saunders, W.P. Sultana, N.; Nawal, R.; Chaudhry, S.; Sivakumar, M.; Talwar, S. Effect of acid etching on the micro-shear bond strength of resin composite–calcium silicate interface evaluated over different time intervals of bond aging. Moussa, S.A. ; Simon, S.; El-Karim, I.; Kundzina, R.; Krastl, G.; Dammaschke, T.; Fransson, H.; Markvart, M.; et al. Properties of NeoMTA plus and MTA plus cements for endodontics. ; Tan, B.C.K. Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview - part I: vital pulp therapy. Zhu, C.; Ju, B.; Ni, R. Clinical outcome of direct pulp capping with MTA or calcium hydroxide: A systematic review and meta-analysis. Dammaschke, T.; Nowicka, A.; Lipski, M.; Ricucci, D. Histological evaluation of hard tissue formation after direct pulp capping with a fast-setting mineral trioxide aggregate (RetroMTA) in humans. Kim, J.R.; Nosrat, A.; Fouad, A.F. Where calcium hydroxide biomaterials were once considered the gold standard of capping materials, mineral trioxide aggregate (MTA) and calcium silicate (CS) are now … doi: 10.1177/0022034516639271. ; Yu, V.S.H. Hong, K. Kwon Dentin Bonding of TheraCal LC Calcium Silicate Containing an Acidic Monomer: An In Vitro Study. Stencel, R.; Kasperski, J.; Pakiela, W.; Mertas, A.; Bobela, E.; Barszczewska-Rybarek, I.; Chladek, G. Properties of experimental dental composites containing antibacterial silver-releasing filler. ; Gokdogan, F.G.; Gundogdu, E. Clinical and radiographic outcomes of direct pulp capping therapy in primary molar teeth following haemostasis with various antiseptics: A randomised controlled trial. Current status of pulp capping with dentin adhesive systems: A review. ; Da Silveira Lima, G.; Carreño, N.L.V. Future in vitro and in vivo studies are necessary to validate the clinical importance of the new generation of light-cured resin-modified calcium silicates; namely, TheraCal LC and ACTIVA BioACTIVE BASE/LINER. The article is aimed at analyzing the available research and comparing the properties of bio-inductive materials in direct and indirect pulp capping procedures. ; Banerjee, A. Samimi, P.; Kazemian, M.; Shirban, F.; Alaei, S.; Khoroushi, M. Bond strength of composite resin to white mineral trioxide aggregate: Effect of different surface treatments. To determine their clinical efficacy, further studies are needed. The Influence of Calcium Chloride on the Setting Time, Solubility, Disintegration, and pH of Mineral Trioxide Aggregate and White Portland Cement with a Radiopacifier. Comparison of the physical and mechanical properties of MTA and portland cement. Choi, Y.; Park, S.J. De Souza, L.C. Antunes Bortoluzzi, E.; Sivieri Araújo, G.; Maria Guerreiro Tanomaru, J.; Tanomaru-Filho, M. Marginal Gingiva Discoloration by Gray MTA: A Case Report. ; Lumley, P.J. Yet, despite the possibility of immediate restoration placing after initial set, there is statistically significant increase in SBS when bonding with Biodentine after a 72-h maturation period [, Although Biodentine offers many advantages over MTA, it presented significantly lower SBS values than MTA to restorative materials, including composite (Filtek Z250, 3M, Saint Paul, MN, USA), compomer (Dyract XP®) and RMGI cement (Photac-Fil Quick Aplicap, 3M, Saint Paul, MN, USA) [. RMGIC’s superior handling properties, quality of bonding with final overlaying restoration and the possibility of immediate restoration placement, might result in more predictable treatments from both a histological and a clinical perspective. ; Lee, S.H. Brizuela, C.; Ormeño, A.; Cabrera, C.; Cabezas, R.; Silva, C.I. The properties and clinical performances of four calcium-silicate cements (ProRoot MTA, MTA Angelus, RetroMTA, Biodentine), a light-cured calcium silicate-based material (TheraCal LC) and an enhanced resin-modified Biodentine. J. ; Park, Y.-J. NIH ; Duarte, M.A.H. Vivan, R.R. Galarça, A.D.; Da Rosa, W.L.D.O. in indirect and direct pulp capping. 2012 Jun;45(6):571-9. doi: 10.1111/j.1365-2591.2012.02013.x. The article is aimed at analyzing the available research and comparing the properties of bio-inductive materials in direct and indirect pulp capping procedures. Abuhaimed, T.S. ; Li, H.B. Find support for a specific problem on the support section of our website. On the other hand, it has been proven that the fluoride ion release of ACTIVA is lower than that of the conventional GI (Keta Molar Quick Aplicap, 3M ESPE, Saint Paul, MN, USA) and also than that of RMGI cement (VitremerTM, 3M-ESPE, Saint Paul, MN, USA) [, The company markets this product as a “light-cured resin-modified calcium silicate” (RMCS) combining uncompromised attributes of both composite and GI [, Comparing to both MTA and Biodentine, ACTIVA BioACTIVE represents a favorable setting time with no delay placing final restoration (, The bioactive properties of ACTIVA BioACTIVE products are based on a mechanism whereby the material responds to pH cycles and plays an active role in releasing and recharging of significant amounts of calcium, phosphate and fluoride [, Despite the fact that ACTIVA BioACTIVE products are RMGICs, the laboratory and clinical findings indicate that the self-adhesive ability of the material is not elucidated [, Considering the material’s characteristics, the application of ACTIVA BioACTIVE in direct and indirect pulp capping might be justified. Shin, H.; Kim, M.; Nam, O.; Lee, H.; Choi, S.; Kim, K. Shear Bond Strength Comparison of Different Adhesive Systems to Calcium Silicate-based Materials. Investigation of the physical properties of tricalcium silicate cement-based root-end filling materials. The promotion of biologically-based treatment strategies has been advocated for partial caries removal aimed at avoiding carious pulp exposure.  |  -. ; Carrilho, E. Biodentine. Subscribe to receive issue release notifications and newsletters from MDPI journals, You can make submissions to other journals. • 3- Tri-calcium phosphate. Vital pulp therapy of mature permanent teeth with irreversible pulpitis from the perspective of pulp biology. Jantarat, J.; Ritsayam, S.; Banomyong, D.; Chaimanakarn, C. Early and 24-hour shear bond strength to dentine of three calcium silicate based pulp capping materials. Fathy, S. Remineralization ability of two hydraulic calcium-silicate based dental pulp capping materials: Cell-independent model. Nagi, S.M. Oral Surg. Bakhtiar H, Nekoofar MH, Aminishakib P, Abedi F, Naghi Moosavi F, Esnaashari E, Azizi A, Esmailian S, Ellini MR, Mesgarzadeh V, Sezavar M, About I. J Endod. Sealing ability of a mineral trioxide aggregate when used as a root end filling material. Mente, J.; Geletneky, B.; Ohle, M.; Koch, M.J.; Friedrich Ding, P.G. Parirokh, M.; Torabinejad, M. Mineral Trioxide Aggregate: A Comprehensive Literature Review—Part III: Clinical Applications, Drawbacks, and Mechanism of Action. Evaluation of the physical and chemical properties of two commercial and three experimental root-end filling materials. ; Felippe, W.T. Managing Carious Lesions: Consensus Recommendations on Carious Tissue Removal. Bogen, G.; Kim, J.S. Flexural strength and flexural fatigue properties of resin-modified glass ionomers. There are only a few studies on novel CSMs, as the scientific evidence is in general focused on materials that have been available for a longer time, such as ProRoot MTA and later Biodentine. ; Aguirre Guedes, O.; Borges, A.H.; Da Silva, A.F. Katge, F.A. Methods for biomimetic remineralization of human dentine: A systematic review. Quispe-Salcedo A, Sato T, Matsuyama J, Ida-Yonemochi H, Ohshima H. Regen Ther. Duncan, H.F.; Galler, K.M. Felman, D.; Parashos, P. Coronal tooth discoloration and white mineral trioxide aggregate. ; Pereira, T.M. ; Bramante, C.M. ; Cooper, P.R. ; Patil, D.P. ; Botelho, M.F. Mineral trioxide aggregate (MTA) apexification: A novel approach for traumatised young immature permanent teeth. 2020 doi: 10.1016/j.joen.2019.11.009. Camilleri, J. Comparison of the radiopacities of different root-end filling and repair materials. ; Zeferino, M.A. ; Song, H.-J. A direct pulp cap is done on permanent teeth when the removal of deep decay results in exposing the pulp. Aksoy, M.K. ; Siboni, F.; Prati, C. Chemical-physical properties of TheraCal, a novel light-curable MTA-like material for pulp capping. ; Tanomaru Filho, M.; Gomes De Moraes, I. Pedano MS, Li X, Yoshihara K, Landuyt KV, Van Meerbeek B. Hargreaves, K.M. It is intended to protect the pulp and be used in deep areas of decay for indirect and direct pulp capping. Would you like email updates of new search results? Barszczewska-Rybarek, I.; Chladek, G. Studies on the curing efficiency and mechanical properties of bis-GMA and TEGDMA nanocomposites containing silver nanoparticles. ; Arikan, V.; Mutluay, M.S. • - Adhere well to dentin and restorative material. Teeth were divided into three groups according to the materials used for pulp capping. In Vivo evaluation of the inflammatory response and IL-6 immunoexpression promoted by Biodentine and MTA Angelus. However, the potential clinical relevance of the difference of 4.32% in the success rates of MTA and Ca(OH) 2 can be discussed. Abou ElReash, A.; Hamama, H.; Abdo, W.; Wu, Q.; Zaen El-Din, A.; Xiaoli, X. Biocompatibility of new bioactive resin composite versus calcium silicate cements: An animal study. ; Lo, E.C.M. 2009) and the PICO framework to address the following clinical questions: ‘Is direct pulp capping a clinically effective treatment for cariously exposed pulps with a diagnosis of reversible pulpitis and does success differ with different pulp capping materials?’ Adv. ; Dehghan, H.; Tamiz, P.; Savadroodbari, M.M. The effects of indirect pulp capping materials CASE REPORT. -, Bjørndal L., Simon S., Tomson P.L., Duncan H.F. Management of deep caries and the exposed pulp. ; Nagaraja, S.; Dinesh, K. Clinical evaluation of mineral trioxide aggregate and biodentine as direct pulp capping agents in carious teeth. ; Chu, C.H. BaklandDirect pulp capping with mineral trioxide aggregate: an observational study. Evaluation of reparative dentin formation of ProRoot MTA, Biodentine and BioAggregate using micro-CT and immunohistochemistry. Sulwińska, M.; Szczesio, A.; Bołtacz-Rzepkowska, E. Bond strength of a resin composite to MTA at various time intervals and with different adhesive strategies. Dispensed in a syringe with a small tip it is easy to place in even the deepest areas of the prep. ; Da Silva, T.M. With Biodentine the same material is used for direct/indirect pulp capping and bulk filling the cavity up to the occlusal surface. Odabaş, M.E. Clinical, Radiographic and Histological Evaluation of Three Different Pulp Capping Materials in Indirect Pulp Treatment of Primary Teeth: A Randomized Clinical Trial: Actual Study Start Date : February 8, 2015: Actual Primary Completion Date : September 15, 2015: Actual Study Completion Date : July 7, 2018: Resource links provided by the National Library of Medicine. 2017 Nov;43(11):1786-1791. doi: 10.1016/j.joen.2017.06.025. Deepa, V.; Dhamaraju, B.; Bollu, I.; Balaji, T. Shear bond strength evaluation of resin composite bonded to three different liners: TheraCal LC, Biodentine, and resin-modified glass ionomer cement using universal adhesive: An in vitro study. ; Lee, H.-S.; Choi, H.-J. TheraCal LC performs as an insulator/barrier and protectant of the Endod. This comparatively new biomaterial is claimed to possess properties similar to MTA and is currently being explored for vital pulp therapy procedures. The pulp capping procedures protects the tissue, but may not reverse a superficial inflammatory processes; therefore, it is recommended that 2–3 mm of tissue is removed in a partial pulpotomy procedure. Direct pulp capping is used when the pulp is visibly exposed (vital pulp exposure) due to caries, trauma, or iatrogenic insult such as accidental exposure during tooth preparation or caries removal. Indirect pulp capping (IPC) is a treatment that preserves pulp's vitality. Vijayran, M.; Chaudhary, S.; Manuja, N.; Kulkarni, A.U. ; Barud, H. Radiopacity and Chemical Assessment of New Commercial Calcium Silicate-Based Cements. Nowicka, A.; Lipski, M.; Parafiniuk, M.; Sporniak-Tutak, K.; Lichota, D.; Kosierkiewicz, A.; Kaczmarek, W.; Buczkowska-Radlińska, J. INDIRECT PULP CAPPING. ; Tomson, P.L. Res. Furthermore, TheraCal cannot be recommended for DPC [, ACTIVA BioACTIVE-BASE/LINER (Pulpdent, USA) was launched in 2014 claiming the strength, aesthetics and physical properties of composites and increased release and recharge of calcium, phosphate and fluoride in comparison with glassionomer (GI). Indirect pulp treatment was applied using Dycal for 91 teeth, … ; Berdal, A.; Simon, S. Biodentine induces immortalized murine pulp cell differentiation into odontoblast-like cells and stimulates biomineralization. Shear bond strength of different restorative materials to mineral trioxide aggregate and Biodentine. 2016;28:58–67. -, Tan S.Y., Yu V.S.H., Lim K.C., Tan B.C.K., Neo C.L.J., Shen L., Messer H.H. ; Bjørndal, L.; Maltz, M.; Manton, D.J. Oral Med. Indirect pulp capping … 30. Costa, C.A. ; Tagami, J. Interfacial characteristics of Biodentine and MTA with dentine in simulated body fluid.

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